researchers from Cardiff University have made a major step forward in the search for a cure for cancer. They have discovered this week that has been reported in an article in the journal Nature Immunology.
The researchers used a variant of the so-called T-cells are found on multiple types of cancer, including breast and lung cancer, it would be able to recognize it. The isolation of the receptor responsible for the recognition, and the subsequent placement of these receptors in other cells, it may in the future result in a product that will allow many cancer patients to be treated.
over the past few years, much progress has been made in the field of cellular therapy. Thanks to T-cells, and certain types of cancer can be treated, but so far it is the only cancer that is in the blood, such as leukemia.
the T-cells are immune cells that are part of the human immune system. If they are isolated from the blood, and is then modified and put back in the body, they are specific proteins, or antigens, recognize them, or even to eliminate, if these cells are malignant. It's called CAR-T immunotherapy.
in the CAR-T cancer, a change of mortality in a chronic illnesswith This CAR-T therapy can be given kankervormen change it from a fatal into a chronic illness. The newly discovered T-cell, it can probably be kankervormen in the tissue and detect such as of the lung, breast, or prostate cancer. Until now, this was not possible.
"It's a big step forward in the inquiry into the treatment of cancer, recognizes the doctor, John Haanen, the Netherlands Cancer Institute (NKI), the research institute of Antoni van Leeuwenhoek. Haanen explores the potential of T-cell therapy in patients with metastatic cancer. In a prospective study of 5 patients, each with a custom-made set of T cells that are specific for their tumor is identified. His institute recently received a so-called ZonMw, grant to the T-cell therapy to be developed.
"There are an awful lot of ifs, ands, or buts. The T-cells, which are only available in mice will be tested. It will take even more years before it can be tested whether this type of therapy for people who cannot work."
types of Cancer with the highest chance of a cure, skin Cancer (squamous cell carcinoma): 94 per cent of skin Cancer (malignant melanoma) of 92 per cent for Prostate cancer in 89 per cent of Breast cancer (invasive): 88% uterine cancer: 79% of 'Safety is our primary concern and you don't want to the healthy cells, destroy'
your Safety is our first priority, insists on Haanen. "You have to make sure that the receptors that the T cells are to be placed only in the malignant cells, to recognize and take off, and it is not the healthy ones," he says. "If there are good proteins that are being identified and disposed of, it can be very detrimental to the patient. But, under the express reserve, you may have the potential, indeed, to speak of a great leap forward."
Two-thirds of the patients who, in 2013, were diagnosed with cancer, five years later, still alive, was found Monday, according to new figures from the Netherlands cancer registry. Over the last five years, an increase in the chance of survival for people who have cancer are given every year by approximately 1 percentage point.
in Fact, the disease is more rapidly detected and effectively countered by new methods of management and treatment, rise in the so-called five year survival, according to the comprehensive Cancer centre the Netherlands (IKNL). At the start of the surveys in 1989, 43% of the patients, five years later, it is still alive.
the Chance of surviving cancer is increasing every year,
, Especially those with breast-, prostate-, (gulp), gut, or kidney cancer are seeing their chances of a cure increase. Also, the chance for cure of many types of blood or lymphatic cancer is increasing. The positive peaks are under the prostaatkankerpatiënten. Almost 90 per cent of the group's five years after the establishment of the diagnosis is still living, an increase of 27 percentage points compared with the first survey.
Btw, these figures are strongly for cancer patients in the western world. The cost of this kind of cell-based therapies are high, a single treatment is currently about 4 tonnes a year. Doctor Haanen believe the price will go down if the treatment is broader and can be used.
types of Cancer with the lowest chance of a cure, Pancreatic cancer: 5 percent (2 percent in 1990, the Lung cancer-21 per cent (from 12 per cent in 1990) Cancer: 23% (8% in 1990) and brain tumours: 24% (18% in 1990) and colon cancer (m).you.d. cardiakanker): up by 25 per cent to 23 per cent in 1990)
Date Of Update: 22 January 2020, 01:00
